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This technology includes using defective interfering (DI) genomes as a therapeutic against various mononegavirales. DI genomes are defective versions of the wildtype viral genome, incapable of replicating by itself but able to interfere with replication of the wildtype virus. We developed both a system to identify and characterize multiple naturally occurring henipaviruses Nipah (NiV) DI genomes species, and a methodology to artificially produce high titer stocks of virions containing these DI genomes, termed DI particles (DIPs).

This technology includes plasmodium falciparum parasites (PH1, Benin, FCQ79, Santa Lucia and Borneo) which have all been isolated from infected persons from various geographic locations and have been modified/adapted for growth in the laboratory for multiple uses. Plasmodium falciparum strain W2 is a parasite clone from a parasite isolate called Indochina III/CDC which in turn originated from a patient in Laos infected with chloroquine-resistant parasites. Gametocytes from W2 can be grown experimentally and used in experimental infection of chimpanzees and aotus monkeys.

This technology includes an optimized influenza A/H9 virus real-time (RT)-PCR assay for detection and characterization influenza A/H9 viruses, which are considered to be one of the most likely candidates to cause an influenza pandemic in humans. The H9 real-time RT-PCR assay will be in compliment with CDC human Influenza Viruses RT-PCR Detection and Characterization Panel to detect of A/H9 influenza viruses.

This technology includes an optimized N.A H7 influenza A virus subtyping real-time (RT)-PCR assay for detection and characterization of N.A A/H7 influenza viruses. Since 1995, infection of poultry with N.A A/H7 influenza viruses has greatly increased, the outbreaks of N.A A/H7 influenza viruses in poultry as well as wild birds occurred many times in Canada, Mexico and USA; meanwhile a number of human infection caused by N.A A/H7 influenza viruses have been confirmed following exposure to infected poultry.

This technology includes compositions useful as inhibitors of acetyltransferase Eis, whose upregulation causes kanamycin (KAN) resistance of tuberculosis (TB) infections, and therefore can be developed and utilized as a treatment for TB. In particular, the compositions are sulfonamide-based and sulfonyl isothiazole-based small molecules. Drug adjuvants in TB represent a conceptually novel approach to combatting a serious global epidemic of drug-resistant TB.

This technology includes methods for the delivery of active bacteriophages or other agents to the lung, with the goal of reducing bacterial colonization and improving clinical outcomes. This is accomplished by encapsulating, immobilizing, or otherwise incorporating bacteriophages to polymer particles in the micro- to nano-scale size range in order to target their delivery to specific lung regions. The current example of this involves poly(lactic-co-glycolic) acid (PLGA) particles conjugated to phages that kill Pseudomonas aeruginosa in the lungs of cystic fibrosis patients.

This technology includes a repository of unique Enterobacteriaceae isolates for various therapeutic and diagnostic uses:

Enterobacter cloacae (Known Acquired Resistance: NDM-1) – Strain 0038

Klebsiella pneumoniae (Known Acquired Resistance: CTX-M-14) – Strain 0079

Citrobacter freundii (Known Acquired Resistance: KPC-2) – Strain 0116

Escherichia coli (Known Acquired Resistance: NDM-1) – Strain 0118

Klebsiella pneumoniae (Known Acquired Resistance: NDM-1) – Strain 0148

Escherichia coli (Known Acquired Resistance: NDM-5) – Strain 0150

This technology includes a real-time polymerase chain reaction (PCR) assay using hydrolysis probe (TaqMan®) chemistry which was developed for detection and type-specific identification of human adenovirus type 4 (HAd4) genomic DNA in clinical specimens. The assay uses unique oligonucleotide primer and probes designed to conserved regions of the HAd4 hexon protein gene. Assay reagents and amplification conditions were optimized and sensitivity and specificity characteristics determined with DNA extracts from multiple HAd4 laboratory strains and other respiratory viral pathogens.

This technology includes therapeutics for Gulf War Illness (GWI). (GWI) patient symptoms, clinical laboratory tests and computational analyses of results from genomic, immunological, autonomic and endocrine changes in animal models therapeutic target were narrowed down to tumor necrosis factor (TNF) and Glucocorticoid receptor for a carefully timed “two hit” treatment model, manipulating cytokine mediated inflammation and the HPA axis.

This technology includes Streptococcus pneumoniae isolates collected through CDC’s Global Strain Bank project with particular serotypes. They were collected as part of routine clinical and surveillance activities and have a wide variety of uses including research, diagnostic, and the development of therapeutics.