Regenerative Therapy for Cartilage Damage
Vitamin C renal leak as a clinical diagnostic tool in the detection, monitoring, and management of acute and chronic diseases
This technology includes a clinical diagnostic tool for measuring vitamin C elimination by human kidneys that can be used for detecting, monitoring, and managing acute and chronic diseases. Findings revealed significant associations between vitamin C renal leak status and clinical variables affecting renal function and blood glucose. The technology uses vitamin C depletion-repletion kinetics and pharmacokinetic models to establish a physiological vitamin C renal threshold.
Antibodies Against TL1A, a TNF-Family Cytokine, for the Treatment and Diagnosis of Autoimmune Inflammatory Diseases
Potential Use of anti-IgE in the Treatment of Lupus Nephritis
Engineering Neural Stem Cells Using Homologous Recombination
Locally Delivered Alkaline Phosphatase for Treatment of Periodontal Disease
DLX3 Knockout Mice for the Study Mouse Models of Tooth, Hair, and Epidermal Defects
This technology includes K14creDLX3 conditional knockout (cKO) mice which will be used to study ectodermal dysplasia disorders such as Amelogenesis Imperfecta, and to study molecular mechanisms of DLX3 regulation in skin and ectodermal appendages. DLX3 is expressed in the epidermis, hair matrix cells in the hair follicle and in the mesenchymal and epithelial compartment of the tooth during embryonic development. To determine the transcriptional network dependent on DLX3-function, we will generate and analyze an epithelial-specific conditional knockout of DLX3.