Technology ID
TAB-4550

DLX3 Knockout Mice for the Study Mouse Models of Tooth, Hair, and Epidermal Defects

E-Numbers
E-013-2015-0
Lead Inventor
Morasso, Maria (NIAMS)
Co-Inventors
Duverger, Oliver (NIDCR)
Applications
Research Materials
Therapeutic Areas
Dermatology
Development Stages
Pre-clinical (in vivo)
Research Products
Animal Models
Lead IC
NIAMS
ICs
NIDCR
NIAMS

This technology includes K14creDLX3 conditional knockout (cKO) mice which will be used to study ectodermal dysplasia disorders such as Amelogenesis Imperfecta, and to study molecular mechanisms of DLX3 regulation in skin and ectodermal appendages. DLX3 is expressed in the epidermis, hair matrix cells in the hair follicle and in the mesenchymal and epithelial compartment of the tooth during embryonic development. To determine the transcriptional network dependent on DLX3-function, we will generate and analyze an epithelial-specific conditional knockout of DLX3.

Commercial Applications
Mouse model to study ectodermal dysplasia disorders and to give further insight into the role of DLX3 gene in skin, hair, and tooth function.

Competitive Advantages
First knockout mouse model of this type.

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Licensing Contact:
Knezevic, Vladimir
vlado.knezevic@nih.gov

Publications

Collaborations

  • Materials Available
  • Licensing

Collaboration Description

  • We are seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology.
Date Published