Reducing Bloodstream Neutrophils as a Treatment for Lung Infection and Inflammation
Novel Activators of Pyruvate Kinase for the Treatment of Hemolytic Anemias
Vectors for the Treatment of Sickle Cell Disease and Beta Thalassemia
Live Attenuated Vaccine to Prevent Disease Caused by West Nile Virus
Diagnostics and Therapeutics for Hydrocephalus
Oral Treatment of Hemophilia
Enhanced GFP-Expressing Human Metapneumovirus (HMPV): A Versatile Tool for Virology Research and Antiviral Drug Screening
The technology involves genetically engineering Human Metapneumovirus (HMPV) to express enhanced green fluorescent protein (GFP), enabling the monitoring of virus infection and gene expression through GFP fluorescence. This system serves as a sensitive and versatile tool for virology research, antiviral drug screening, and diagnostic applications.
Advanced Human Cell Line Technology for RSV Replication Complex Production and Antiviral Drug Discovery
This technology includes the NeurEx® mobile application, a groundbreaking tool designed for neurologists to conduct and document neurological examinations efficiently. Deployed on iPads, it integrates with a secure, cloud-based database, automating the computation of four key disability scales used in neuroimmunology. The app's robust design enables precise mapping of neurological deficits, blending spatial distribution with quantitative assessments.
Stable Cell Line Technology for Enhanced Production of Varicella-Zoster Virus Vaccines
This technology includes a stable cell line engineered to have reduced expression of the pro-apoptotic protein Bim when exposed to doxycycline. This reduction in Bim expression allows for significantly higher yields of the Varicella-Zoster Virus (VZV), which is used in the production of live, attenuated VZV vaccines. The enhanced viral production makes this cell line particularly useful for vaccine manufacturing.