Compatible 3-D Intracardiac Echography Catheter and System for Interventional Cardiac Procedures
Vitamin C renal leak as a clinical diagnostic tool in the detection, monitoring, and management of acute and chronic diseases
This technology includes a clinical diagnostic tool for measuring vitamin C elimination by human kidneys that can be used for detecting, monitoring, and managing acute and chronic diseases. Findings revealed significant associations between vitamin C renal leak status and clinical variables affecting renal function and blood glucose. The technology uses vitamin C depletion-repletion kinetics and pharmacokinetic models to establish a physiological vitamin C renal threshold.
Apparatus for Cryogenic-Electron Microscopy Sample Preparation
Cryo-Electron Microscopy (cryo-EM) is used to obtain high-resolution structural images of macromolecular structures. Samples must be purified and loaded onto cryo-EM grids before imaging. The ideal cryo-EM grid consists of particles that are evenly and richly distributed in a broad distribution of orientations throughout the holes of the support film. Current techniques to prepare cryo-EM grids are performed manually and require trial and error, resulting in a bottleneck in cryo-EM workflows.
Synthetic Bacterial Nanoparticles as Drug and Vaccine Delivery Vehicles
Bacterial spores can be modified to display molecules of interest, including drugs, immunogenic peptides, antibodies and other functional proteins of interest (such as enzymes). The resulting engineered bacterial spores can provide many useful functions such as the treatment of infections, use as an adjuvant for the delivery of vaccines, and the enzymatic degradation of environmental pollutants.
Method for High-Throughput Microdissection and Analysis of Biological Samples
The National Cancer Institute's Laboratory of Pathology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a method for target-activated microdissection.
Polarimetric Accessory for Colposcope
In medical diagnostic procedures for examining the cervix and the tissues of the vagina and vulva, long working-distance (-30 cm) lighted binocular microscopes (colposcope) that provide up to 25x optical magnification are used to create an illuminated magnified view. Speculum dilations can give rise to specular reflections from the tissue surface, causing physicians to overlook possible abnormalities – thus decreasing the quality of a colposcopy.
Excellence in Technology Transfer
For the development of an indicator device to detect food quality.
Awardees
Food and Drug Administration
- Dr. Jon G. Wilkes
- Dr. Dwight W. Miller
High-Speed Counter Current Chromatography
The pool of potential medicinal candidates found in natural products is vast. One section of one plant can contain thousands of potential candidate compounds. Natural products research has become increasingly interesting to pharmaceutical companies engaged in new drug discovery. As a result, a device is needed that will extract candidate compounds more efficiently and cost-effectively.