Methods for Using Modulators of Extracellular Adenosine or an Adenosine Receptor To Enhance Immune Response and Inflammation
Retinoids Can Increase the Potency of Anti-Cancer Immunotoxins
Methods of Inducing Deacetylase Inhibitors to Promote Cell Differentiation and Regeneration
Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2
Modified Defensins and Their Use
Peptides for Treatment of Tumor Necrosis Factor alpha Mediated Inflammatory Disease
Factors That Bind Intestinal Toxins
Bacterial infections not only cause disease by their presence but also upon the release of toxins. The common enteric bacteria, E. coli O157:H7 releases such toxins (Stx-1) upon treatment with antibiotics. These toxins, when released into the lumen of the intestinal tract, will cause cellular damage thus increasing the severity of the infection.
Method for the Treatment of Multiple Sclerosis
Interleukin 24 (IL-24) to treat inflammatory diseases
Proinflammatory T-helper 17 cells (Th17) play important roles in host immune defense against infection, but uncontrolled activation of these cells, known as the Th17 response, may cause autoimmune and autoinflammatory diseases (uveitis, multiple sclerosis, rheumatoid arthritis, and Crohn’s disease) through the effects of Th17 lineage cytokines (such as, IL-17F, IL-22 and GM-CSF). Importantly, IL-17A (a proinflammatory cytokine) represses other Th17 lineage cytokines by upregulating the regulatory cytokine IL-24.