Identification Of The Gene Causing Familial Mediterranean Fever
Staphylococcus Epidermidis Isolates from Human Skin Samples for Use as Clinical Molecular Markers
Locally Delivered Alkaline Phosphatase for Treatment of Periodontal Disease
Five Human Embryonic Stem Cell (hESC) Lines with Reporters for Stem Cell Biology Research
DLX3-floxed mice (DLX3f/f) for Use in Drug Development and In Vivo Research Studies for Ectodermal Dysplasia Disorders
This technology includes the creation of DLX3-floxed mice, specifically designed for conditional deletion of the DLX3 gene via Cre-mediated recombination. This innovative approach aims to develop mouse models for studying ectodermal dysplasia disorders. Ectodermal dysplasias are a diverse group of genetic conditions affecting the development of ectodermal structures, including hair, teeth, and bones. The DLX3f/f mice are particularly valuable for modeling specific disorders such as Tricho-dento-osseous syndrome (TDO), Amelogenesis Imperfecta (AI), and Dentinogenesis Imperfecta (DI).
DLX3 Knockout Mice for the Study Mouse Models of Tooth, Hair, and Epidermal Defects
This technology includes K14creDLX3 conditional knockout (cKO) mice which will be used to study ectodermal dysplasia disorders such as Amelogenesis Imperfecta, and to study molecular mechanisms of DLX3 regulation in skin and ectodermal appendages. DLX3 is expressed in the epidermis, hair matrix cells in the hair follicle and in the mesenchymal and epithelial compartment of the tooth during embryonic development. To determine the transcriptional network dependent on DLX3-function, we will generate and analyze an epithelial-specific conditional knockout of DLX3.
Mouse Model of Pompe Disease for Therapy Discovery
This technology includes a mouse model of Pompe disease, created by targeted inactivation of the acid alpha-glucosidase gene, to test novel therapies. Pompe disease is a severe muscle disorder that affects people at any age. It is a rare genetic disease caused by a deficiency of a lysosomal enzyme acid alpha-glucosidase. The enzyme degrades glycogen to glucose in the lysosomes. The deficiency leads to accumulation of glycogen in multiple organs, but cardiac and skeletal muscles are most severely affected.
Monoclonal Anti-mouse and Anti-human TL 1A Antibodies for Diagnostic and Therapeutic Utilization
This technology includes antibodies against TL 1A for the inhibition of TL 1A-DR3 interactions for the diagnosis and treatment of various autoimmune diseases. Through the use of our developed hamster anti-mouse and mouse anti-human monoclonal antibodies, we’ve demonstrated that treatment with anti-mouse TL 1A prevented collagen-induced arthritis and TNBS-induced colitis NEED TO UPDATE
A Phospho-specific antibody to Fc “epsilon” R1 “gamma” as a Diagnostic Tool for Allergic Reactions
This technology includes a mouse monoclonal antibody that recognizes the phosphorylated form of the FceRiy which could be used as a diagnostic tool during allergic reactions. The FcERI is central to the activation of mast cells and basophils and activation of this receptor induces these cells to secrete mediators that cause allergic symptoms. This antibody specifically recognizes the phosphorylated tyrosine 47 (Y 47) of the FceRiy. Phosphorylation of this site Indicates that this receptor is in an active state and thus the cells can secrete allergic mediators.