A plasmid encodes human formyl peptide receptor-like 1 (FPRL1/FPR2).

Plasmid DNA (clone pNL4-3) that produces infectious HIV-1 virus particles in a wide variety of cells as described in the J Virol. 1986 Aug;59(2):284-91 and developed in the laboratory of Dr. Malcolm Martin at the National Institute of Allergy and Infectious Diseases.

A plasmid encodes human C-C chemokine receptor type 2 (CCR2). CCR2 play important roles in the recruitment of monocytes/macrophages and T cells.

A plasmid encodes human C-C motif chemokine receptor 3 (CCR3). It may contribute to the accumulation and activation of eosinophil and other inflammatory cells in the allergic airway.

A plasmid encodes mouse C-C motif chemokine receptor 1 (CCR1). CCR1 plays an important role in host protection from inflammatory response, and susceptibility to virus and parasite.

Plasmids encode regulators of G protein signalling (RGS).

Plasmid pSJ136-EF-A — A plasmid encoding mutant anthrax toxin proteins such as lethal factor (LF) or edema factor (EF). Anthrax toxin and anthrax toxin fusion proteins may be used as therapeutic agents for cancer.

Plasmid PSJ115-LFOS — A plasmid expressing anthrax toxin proteins such as lethal factor (LF) or edema factor (EF) which has the original n-terminal amino acid sequence.

The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia is also the leading cause of preventable blindness in the world. Despite increased surveillance, prevalence continues to increase, and the need to develop an effective chlamydial vaccine remains.

Technologies:

A hybridoma cell line producing a monoclonal rat antibody specific to mouse CD25 (IL-2 receptor) (clone 7D4) as described in Proc Natl Acad Sci U S A. 1983 Sep;80(18):5694-8 and developed by the laboratory of Dr. Ethan Shevach at the National Institute of Allergy and Infectious Diseases.

A hybridoma cell line producing a monoclonal rat antibody specific to mouse CD25 (IL-2 receptor, alpha chain) (clone 3C7) as described in J Immunol. 1984 Oct;133(4):1970-5 and developed by the laboratory of Dr. Ethan Shevach at the National Institute of Allergy and Infectious Diseases.