Targeting the 5’UTR of Survival Motor Neuron 2 (SMN2) with Antisense Oligonucleotides to Increase Expression for the Treatment of Spinal Muscular Atrophy
Preparation of Substituted Diarylpropanamides as RORgt Antagonists for the Treatment of Th17-related Autoimmune Diseases
Discovery of imidazo[1,2-b]pyridazines with Anticancer Properties
Gene Therapy for Cobalamin C Deficiency (cblC) with Viable Mouse Models
Handwipe Disclosing Method for Detecting the Presence of Lead
Wipes and Methods for Removal of Lead and Other Metal Contamination from Surfaces
Methods of Predicting Patient Treatment Response and Resistance via Single-Cell Transcriptomics of Their Tumors
Tailoring the best treatments to cancer patients remains a highly important endeavor in the oncology field. However, personalized treatment courses are challenging to determine, and technologies or methods that can successfully be employed for precision oncology are lacking.
Molecular Nanotags for Detection of Single Molecules
Biological nanoparticles, like extracellular vesicles (EVs), possess unique biological characteristics making them attractive therapeutic agents, targets, or disease biomarkers. However, their use is hindered by the lack of tools available to accurately detect, sort, and analyze. Flow cytometers are used to sort and study individual cells. But, they are unable to detect and sort nanomaterials smaller than 200 nanometers with single epitope sensitivity.
Exo-Clean Technology for Purifying Extracellular Vesicle Preparations from Contaminants
Extracellular Vesicles (EVs), including exosomes and microvesicles, are nanometer-sized membranous vesicles that can carry different types of cargos, such as proteins, nucleic acids and metabolites. EVs are produced and released by most cell types. They act as biological mediators for intercellular communication via delivery of their cargos. This unique ability spurred translational research interest for targeted delivery of therapeutic molecules to treat a wide range of diseases. EVs also contain interesting information of their specific cellular origin.