Through a CRADA with EMD Serono, NCI played an instrumental role in developing and
expediting regulatory approval of EMD Serono’s checkpoint inhibitor, avelumab. Avelumab
received FDA approval in 2017, only four years after EMD Serono and NCI added the study of
avelumab to their CRADA. This was a remarkably fast developmental and regulatory approval
timeline.
Rotavirus is a disease that affects nearly every child worldwide. While most cases have mild symptoms, it is responsible for one third of infant hospitalizations for severe diarrhea and kills an estimated 200,000 children a year, mostly in developing countries. Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) developed vaccine formulations to address the six most common forms of rotavirus.
Rotavirus is a disease that affects nearly every child worldwide. While most cases have mild symptoms, it is responsible for one third of infant hospitalizations for severe diarrhea and kills an estimated 200,000 children a year, mostly in developing countries. Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) developed vaccine formulations to address the six most common forms of rotavirus.
CDC NIOSH early technology to detect surface contamination by hazardous antineoplastic drugs. Antineoplastic drugs, also known as anti-cancer drugs or chemotherapy, are used in the treatment of many types of cancer. While these drugs are lifesaving to patients, they must be handled with care by healthcare workers. Exposure from contaminated surfaces and drug vials can cause skin problems, birth defects, reproductive issues, and increased risk of various cancers.
CDC NIOSH early technology to detect surface contamination by hazardous antineoplastic drugs. Antineoplastic drugs, also known as anti-cancer drugs or chemotherapy, are used in the treatment of many types of cancer. While these drugs are lifesaving to patients, they must be handled with care by healthcare workers. Exposure from contaminated surfaces and drug vials can cause skin problems, birth defects, reproductive issues, and increased risk of various cancers.
The National Institute for Allergy and Infectious Diseases (NIAID) has been recognized by the FLC for their impact on the public through their technology transfer work. On February 21, 2020 NIAID’s Division of Microbiology and Infectious Diseases (DMID) started an Adaptive COVID-19 Treatment Trial (ACTT) to test Gilead’s antiviral drug remdesivir, in a phase 3 trial. Remdesivir is an inhibitor of the viral RNA polymerase, so it became an early therapeutic candidate for COVID-19. This was the first clinical trial in the U.S. for an experimental treatment for COVID-19.
The Centers for Disease Control and Prevention (CDC) and the National Institute for Allergy and Infectious Diseases (NIAID) have been rewarded for their partnership from the 2021 Federal Laboratory Consortium (FLC) awards. The CDC and NIAID had already developed a new approach to sharing samples during a Public Health Emergency of International Concern (PHEIC) during the Zika pandemic, which enabled them to respond quickly and efficiently to access and share samples of SARS-CoV-2 early in the outbreak.
Within hours of the public release of the viral genome sequence, scientists at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID) and their collaborators engineered a key protein from SARS-CoV-2, the virus that causes COVID-19, to enable its study as a vaccine candidate and for research applications.
The Technology Transfer and Intellectual Property Office (TTIPO)
Originally established to study influenza, a partnership between NIAID and biotechnology company AbCellera quickly pivoted to become a major player in the development of antibodybased COVID-19 therapies. One of those therapies, bamlanivimab, has been authorized to treat mild to moderate COVID-19 symptoms in patients who are at risk for more severe disease, when combined with another antibody.