Interleukin-2 Receptor Gamma Deficient Mice, Widely Used Research Tools

In 1995, Dr. Warren J. Leonard of the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), reported the creation of an interleukin-2 receptor gamma chain (IL-2Rg) deficient mouse. His lab also demonstrated earlier that mutations in the gene encoding IL-2Rg result in X-linked severe combined immunodeficiency (XSCID) and that IL-2Rg is a subunit common to multiple cytokine receptors. The IL-2Rgdeficient mice created by Dr. Leonard provide a unique animal model, the first of its kind, to study XSCID and other immune deficiencies.

Cristina Thalhammer-Reyero

Dr. Thalhammer-Reyero joined the OTT in 2001. Prior to joining NIH, she was the founder and president of a start-up company, where she developed and patented inventions in the area of computational biology. In earlier years, Dr. Thalhammer-Reyero held various faculty and academic research positions in the areas of immunology, cell biology, cancer biology and biochemistry at Northeastern University, the University of Heidelberg in Germany, Yale University and the University of Vienna in Austria. Dr.

Michael Shmilovich

Michael joined the OTT in 2003. Prior to joining NIH OTT, Michael practiced law at a Washington, DC law firm’s patent division. Before attending law school, he was a biologist at NINDS and NIMH working in the area of clinical genetics. Michael received a degree in law (J.D.) from American University, Washington College of Law, a B.S. in molecular biology and genetics from the University of Michigan, Ann Arbor, and is continuing his scientific education with graduate level immunology courses at the Foundation for the Advanced Education in the Sciences.

Uri Reichman

Dr. Reichman joined the OTT in December 1999. Prior to joining the NIH, Dr. Reichman worked for twenty years (1980-1999) in the biotechnology industry, specializing in the field of medical diagnostics. From 1973 to 1980, Dr. Reichman conducted academic research at Sloan Kettering Institute for Cancer Research in New York. Dr. Reichman is an author of 26 scientific papers and an inventor on several patents. Dr. Reichman received his Ph.D. in Medicinal Chemistry from the Hebrew University in Jerusalem, Israel, and obtained an M.B.A. degree from Iona College in New York.