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Ellipsoid zone (EZ) loss has been proposed as evidence of progression of several retinal degenerative diseases, including, but not limited to, retinitis pigmentosa and hydroxychloroquine (HCQ)-induced retinal toxicity. HCQ is a first-line drug used to treat autoimmune diseases such as systemic lupus
The mission of NIMH is to translate the understanding and treatment of mental illnesses through basic and clinical research leading to prevention, recovery and cure. Many pharmaceutical companies generally prefer to invest in more profitable disease areas. NIMH Intramural Research Program (IRP)
Over 300 million people worldwide are suffering from chronic depression. It is also one of the leading causes of disability in US and can be fatal as suicide kills more than 45,000 Americans annually. NIMH psychiatrist Dr. Carlos Zarate and collaborators discovered that a single intravenous dose of
Dr. Wiliam J. Pavan and his team at National Human Genome Research Institute (NHGRI) have established a novel diagnostic tool to predict time of onset for the rare neurodegenerative Niemann-Pick disease type C (NPC). The npc1 gene mutation leads to the lysosomal lipid storage disorder in neuronal