Technology ID
TAB-830

Regulation of RNA Stability

E-Numbers
E-314-2002-0
Co-Inventors
Lai, Wi
Applications
Therapeutics
Research Materials
Diagnostics
Lead IC
NIEHS
This invention relates to the discovery that tristetraprolin (TTP) can promote the poly(A)RNase (PARN) mediated deadenylation of polyadenylated substrates containing AU-rich elements (AREs). As one aspect of the invention, the inventors have developed a cell free system that may be used for the purposes of assessing the effects of the various system components or their derivatives (i.e. AREs, PARN, or TTP) on the deadenylation process or the effects of various test agents on the deadenylation process.

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Patents

  • US
    Provisional (PRV) 60/451,976
    Filed on 2003-03-06
    Status: Abandoned
  • Patent Cooperation Treaty
    (PCT) PCT/US2004/06703
    Filed on 2004-03-05
    Status: Abandoned

Publications

  • Aspects of this work have been published as follows: WS Lai et al., "Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease," Mol. Cell Biol. 2003 June 23(11):3798-3812.

Collaborations

  • Licensing
  • Collaboration

License Status

  • This technology is available for licensing on an exclusive or a non-exclusive basis. In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.
Date Published