Next generation MRI platform Signal Amplification by Reversible Exchange (SABRE) hyperpolarization
Hyperpolarized magnetic resonance imaging (MRI) is an emerging molecular imaging method for metabolic imaging for detecting cancer, cardiovascular disease, stroke, and traumatic brain injury and monitoring therapy with no Gadolinium or Iron. Available for licensing and commercial development is a patent estate covering a perfluorinated single amplification by reversible exchange (SABRE) catalyst for generating MRI agents that includes a d-block element and a perfluorinated ligand hyperpolarized substrate comprising a 1/2 spin nucleus or nuclei using the perfluorinated SABRE catalysts, and isolating the resulting hyperpolarized substrate for administration. The invention also provides methods for separating a hyperpolarized substrate from the SABRE catalyst and/or hyperpolarized SABRE catalyst complex containing a heavy metal. These changes can be observed in patients in real time with a specialized MRI approach called hyperpolarization. By transiently changing the nuclear spin of naturally occurring intermediates in cellular energy production, the metabolic fate can be observed with greater than 10,000-fold sensitivity. Current methods of hyperpolarization require expensive machines with limited throughput.
- MRI imaging
- Hyperpolarization
- Infusion Device for imaging reagents
- Cancer diagnostics
- Cardiovascular disease diagnostics
- High Sensitivity: Over 10,000-fold sensitivity improvement.
- Cost Efficiency: Avoids expensive hyperpolarization machines.
- Metal-Free Imaging: No gadolinium or iron required.
- Real-Time Monitoring: Enables immediate observation of metabolic changes.