Technology ID
TAB-4566

Neural Stem Cells from an iPSC Line Ubiquitously Expressing Green Fluorescent Protein for Basic Science Research and Cell Line Tracking

E-Numbers
E-610-2013-0
Lead Inventor
Malik, Nasir (National Inst of Arthritis and Musculoskeletal and Skin Diseases)
Co-Inventors
Rao, Mahendra (New York Stem Cell Foundation)
Applications
Research Materials
Therapeutic Areas
Neurology
Development Stages
Pre-Clinical (in vitro)
Research Products
Human Cell Lines
Lead IC
NIAMS

This technology involves neural stem cells (NSCs) derived from pluripotent stem cells (PSCs) that can differentiate into neurons and glia. The key feature of this technology is the CY2 EEF1A1 GFP iPSC line, which includes a green fluorescent protein (GFP) expressed under the EEF1A1 promoter, leading to its ubiquitous expression in cells. This characteristic makes the NSCs and the neural cells differentiated from this line exhibit green fluorescence. Such cells, when transplanted into animal models like mice and rats, can be easily tracked due to their fluorescence. This tracking is critical for assessing whether these cells have successfully integrated into the host's nervous system and are functioning properly. The primary advantage of this technology is that the GFP expression allows for easier tracking of the transplanted cells in comparison to most other NSC lines which lack such fluorescent reporters. This technology has potential applications in studying the integration and functionality of transplanted neurons and astrocytes in animal models, providing significant insights into neural cell behavior and treatment efficacy.

Commercial Applications
This technology has potential applications in neurological research and therapy, particularly in studying the integration and functionality of transplanted neurons and astrocytes in animal models, enhancing our understanding of neural cell behavior and treatment possibilities.

Competitive Advantages
The competitive advantage of this technology lies in its unique ability to track transplanted neural stem cells easily in animal models, thanks to the ubiquitous expression of green fluorescent protein, a feature not commonly found in other NSC lines.

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Licensing Contact:
Knezevic, Vladimir
vlado.knezevic@nih.gov

Collaborations

  • Materials Available

Collaboration Description

  • We are seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology.
Date Published