Technology ID
TAB-4556
Cell Lines of Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cell (iPSC) lines for Multiple Neurological Therapeutic and Diagnostic Uses
E-Numbers
E-092-2012-0
Lead Inventor
Rao, Mahendra (National Institute of Arthritis and Musculoskeletal and Skin Diseases)
Applications
Research Materials
Therapeutic Areas
Neurology
Development Stages
Pre-Clinical (in vitro)
Research Products
Human iPSC Lines
Lead IC
NIAMS
This technology includes three cell lines of dopaminergic neurons derived from human induced pluripotent stem cell (iPSC) line BC1, human iPSG line X1 and human embryonic stem cell (hESC) line H14 to be utilized in neurology research. These cell lines will be used for to study the biology of brain development and may also be used to test different characterization and differentiation assays. The dopaminergic neurons and/or their derivatives may also be used as controls in studies to screen for small molecules to change cell fate and/or to alleviate the phenotypes of various diseases.
Commercial Applications
These cell lines will be used in many studies that could facilitate the development of cellular therapies, more effective drug treatments through their use as screening assays, and improved understanding of basic cell biology.
Competitive Advantages
The starting materials (iPSC-BC1, iPSC-X1, and hESC-H14) are all available commercially and do not restrict the usage of their derivatives, and these cells will significantly reduce the financial burden of initiating many research projects.
Licensing Contact: