Technology ID
TAB-4539
Transgene Free Non-human Primate Induced Pluripotent Stem Cells (iPSCs) for Use in Pre-clinical Regenerative Medicine Research
E-Numbers
E-248-2014-0
Lead Inventor
Dunbar, Cynthia (National Heart, Lung and Blood Institute (NIH/NHLBI))
Co-Inventors
Hong, So Gun (NHLBI)
Winkler, Thomas (NHLBI)
Applications
Research Materials
Development Stages
Pre-Clinical (in vitro)
Research Products
Human iPSC Lines
Animal Models
Lead IC
NHLBI
ICs
NHLBI
This technology includes rhesus macaque induced pluripotent stem cells (iPSCs) lines from multiple animals and various types of cells to establish this pre-clinical model. iPSCs are a type of pluripotent stem cell that can be generated from adult somatic cells. The iPSC technology holds great potential for regenerative medicine. Before clinical application, it is critical to evaluate safety and efficacy in a clinically-relevant animal model. We propose that non-human primate models are particularly relevant to test iPSC-based cell therapies.
Commercial Applications
Potentially rhesus iPSC lines can be differentiated into any cell type of the organism, therefore, rhesus iPSCs are valuable for optimizing differentiation protocols and assessing their safety and efficacy before beginning clinical applications in regenerative medicine.
Competitive Advantages
Our iPSCs are transgene-free, containing a 303bp non-expressed, non-enhancer containing tag for in vivo tracking, and have been shown in vitro and in vivo to give rise to functional tissue.
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