Technology ID
TAB-3758
Mouse Models for the Study of Male Fertility
E-Numbers
E-141-2012-0
Lead Inventor
Simons, S. Stoney (NIDDK)
Co-Inventors
He, Yuanzheng (Van Andel Institute)
Lee, Geun-Shik
Applications
Therapeutics
Research Materials
Therapeutic Areas
Ophthalmology
Oncology
Infectious Disease
Endocrinology
Dental
Cardiology
Lead IC
NIDDK
ICs
NIDDK
This technology includes two mouse models to be used in studying male sterility. One mouse is deficient in the full-length protein for STAMP/TtH5. The second is a conditional mutant STAMP mouse that can be used to produce tissues/organs that are deficient in full length STAMP. STAMP represents an intriguing new protein in the study of male fertility. More detailed future studies should identify the precise defect(s) leading to male sterility and may identify other behavioral and developmental consequences, such as a role in the immune system that is suggested by the microarray studies.
Commercial Applications
More detailed future studies should identify the precise defect(s) leading to male sterility and may identify other behavioral and developmental consequences, such as a role in the immune system that is suggested by the microarray studies.
Competitive Advantages
First development of these two mutant mice.
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