Technology ID
TAB-3707
A Neuronal Induced Pluripotent Stem Cell (iPSC) Line with CRIPSR Inhibition Gene Knockdown
E-Numbers
E-124-2020-0
Lead Inventor
Ward, Michael (National Institute of Neurological Disorders and Stroke)
Applications
Therapeutics
Research Materials
Therapeutic Areas
Neurology
Research Products
Research Equipment
Lead IC
NINDS
This technology includes the combination of an induced pluripotent stem cell (iPSC) line that can inducibly be differentiated into neurons (using an inducible Neurogenin 2, Ngn2, cassette) and enable CRISPR inhibition gene knockdown (via stable expression of dCas9-BFP-KRAB). The combination of these elements in a cell line enables multiple lines of research, including small molecule screens for drug development in neuronal disease models, as well as studying stem cell biology in an iPSC neuronal cell model.
Commercial Applications
The neuronal stem cell line permits screens by commercial entities for drug development or target identification in iPSC neurons.
Competitive Advantages
The NCRM5 iPSC line is an NIH resource and resulting cell lines should be more easily shared with other institutions than from other parental lines (e.g., WTC11).
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