Technology ID
TAB-3690
Anti-Atlastin-1 Mouse Monoclonal Antibody 3194 (lgG1) For Studying Hereditary Spastic Paraplegia (SPG3A)
E-Numbers
E-129-2015-0
Lead Inventor
Blackstone, Craig (National Institute of Neurological Disorders and Stroke)
Co-Inventors
Zhu, Peng Peng (National Institute of Neurological Disorders and Stroke)
Applications
Research Materials
Therapeutic Areas
Neurology
Immunology
Research Products
Antibodies
Lead IC
NINDS
This technology includes the creation and use of a mouse anti-Atlastin-1 monoclonal antibody (3194, IgG1). Mutations in Atlastin-1 are commonly found in hereditary spastic paraplegia, SPG3A. In addition, this protein is conserved in all eukaryotes, and it mediates fusion of endoplasmic reticulum tubules in cells, giving it its characteristic polygonal appearance. Thus, this protein is of interest to both those interested in disease pathogenesis and those studying basic cell biology.
Commercial Applications
This anti-Atlastin-1 monoclonal antibody can be used for immunoblotting and immunocytochemistry to detect this protein.
Competitive Advantages
Companies and other laboratories have generated polyclonal antibodies against this same epitope, based on our original publication, but to our knowledge no one else has developed a monoclonal antibody with this specificity.
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