O-GlcNAc Transferase (OGT) Inhibitors for the Treatment of Cancer and Viral Infections

This technology includes small molecule inhibitors of O-linked N-acetyl glucosamine (OGlcNAc) transferase (OGT) as molecular probes to better understand OGT function in cell homeostasis, and to eventually be used as therapeutic agents against cancer and to reduce viral replication. OGT is a ubiquitous enzyme catalyzing the transfer of N-acetylglucosamine to the serine or threonine residues of nuclear and cytoplasmic proteins. This cellular process is tightly regulated and is sensitive to levels of cellular stress and of nutrients levels. In addition, OGT modulation may inform on the metabolic reprograming of cancer cells. The inhibitors developed show on-target OGT engagement, as judged by several readouts but does not appear to alter N- or O-glycan structures substantially.