Technology ID
TAB-3546
New Antimalarial Chemotypes Discovered Through Chemical Methodology and Library Development
E-Numbers
E-221-2011-0
Lead Inventor
Synder, John (Boston University)
Co-Inventors
Inglese, James (National Human Genome Research Institute (NIH/NHGRI))
Cheng, Chih-Chien (Ken) (NCATS)
Macarthur, Ryan (NCATS)
Guha, Rajarshi (NCATS)
Su, Xin-zhuan (NIAID)
Yuan, Jing (NIAID)
Ni, Feng (Boston University)
Beeler, Aaron (Boston University)
Schaus, Scott (Boston University)
Brown, Lauren (Boston University)
Porco, John (Boston University)
Applications
Therapeutics
Therapeutic Areas
Infectious Disease
Lead IC
NCATS
ICs
NIAID
NCATS
This technology includes three new compound classes displaying either differential or comprehensive antimalarial activity across geographically diverse lines. These compounds were identified from a quantitative high throughput screen of a novel chemical library with unique chemical complexity and are potential candidates for treating malaria.
Commercial Applications
This new compound class will be utilized to treat malaria.
Competitive Advantages
Compounds display comprehensive antimalarial activity.
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