This technology includes a device to allow chemists to process crude reaction mixtures with the objective of isolating the desired product from reaction by-products and other solvents and impurities to provide material of adequate quality and purity to be submitted for further chromatographic purification or used directly in subsequent reactions. The instrument serves in facilitating the integration of a close-to-universal set of isolation techniques collectively referred to as “solid-phase extraction” (SPE) methods. Alternatively, depending on the overall chemistry objective sought by the user, the media may also selectively absorb impurities or byproducts while desired material is eluted through the media.