Technology ID
TAB-3480
Development of a Polyclonal Antibody for Neuroligin 4 pThr707 and a Polyclonal Antibody for Neuroligin 1 pTHR739
E-Numbers
E-002-2015-0
Lead Inventor
Roche, Katherine (NINDS)
Co-Inventors
Bemben, Michael (NINDS)
Badger, John (NINDS)
Applications
Research Materials
Diagnostics
Therapeutic Areas
Neurology
Immunology
Research Products
Antibodies
Lead IC
NINDS
ICs
NINDS
This invention includes the generation and use of two polyclonal antibodies that specifically recognizes the phosphorylation site pThr707 of Neuroligin 4 and pThr739 of Neuroligin 1. A peptide of the site around the phosphorylation site was generated and injected into rabbits to create an immune response. Serum was collected from the rabbits that was then affinity purified. The specificity of the resulting polyclonal antibodies was then determined using biochemical techniques.
Commercial Applications
The polyclonal antibodies can be used for studying phosphorylated Neuroligin 1 and Neuroligin 4.
Competitive Advantages
These antibodies are specific to the sites and can be used to detect phosphorylation of the amino acid at this specific site.
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