Technology ID
TAB-2955

WNT1-Induced Secreted Protein-1 Knockout Mouse Model

E-Numbers
E-234-2015-0
Lead Inventor
Young, Marian (NIDCR)
Co-Inventors
Maeda, Azusa (Okayama University Graduate School of Medicine)
Ono, Mitsuaki (Okayama University Graduate School of Medicine)
Applications
Therapeutics
Research Materials
Diagnostics
Therapeutic Areas
Ophthalmology
Oncology
Infectious Disease
Immunology
Geriatrics
Endocrinology
Dental
Cardiology
Development Stages
Pre-Clinical (in vitro)
Development Status
In vivo data available (animal)
Lead IC
NIDCR
ICs
NIDCR

WNT1-induced secreted protein-1 (WISP1) is expressed at high levels in osteoblasts and their precursors. WIPS1 plays an important role in various aspects of bone formation. Scientists at the NIH generated Wisp1-deficient (Wisp1-/-) mice. Deletion of Wisp1 resulted in a decrease in bone mineral density, total bone volume, bone thickness, and biomechanical strength. Wisp1 knockout mouse model can be used to study the molecular mechanisms of bone turnover and patho/physiology of tissues that express WISP1. The animal is only available from MMRRC.

Commercial Applications
  • To study the molecular mechanisms of bone formation and osteodifferentiation.
  • To study the patho/physiology of tissues that express WISP1, including cartilage during osteoarthritis, healing skin, and other soft tissues including lung, pancreas, and heart.

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Licensing Contact:
Knezevic, Vladimir
vlado.knezevic@nih.gov

Publications

Date Published