Technology ID
TAB-2700
Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples
E-Numbers
E-335-2013-0
Lead Inventor
Morrison, Christine (CDC)
Co-Inventors
Hinrikson, Hans (CDC)
Applications
Therapeutics
Research Materials
Occupational Safety and Health
Diagnostics
Consumer Products
Therapeutic Areas
Ophthalmology
Oncology
Infectious Disease
Endocrinology
Dental
Cardiology
Development Stages
Pre-Clinical (in vitro)
Development Status
In vitro data available
Research Products
Research Equipment
Lead IC
CDC
ICs
CDC
This invention relates to assays for the detection and species-specific identification of Aspergillus fungi. Accurate clinical diagnosis of Aspergillus species has become increasingly important as certain species, such as A. terreus and A. fumigatus, are resistant to specific commonly employed antifungal compounds. Most contemporary fungal diagnostic methods are time-consuming and inaccurate. This invention directly addresses those inadequacies by providing a method to rapidly and accurately differentiate all medically important species of Aspergillus based on differences in the DNA sequences of the internal transcribed spacer 1 region of ribosomal DNA.
Commercial Applications
- Directing antifungal drug therapy for improved patient outcomes
- Detection, discrimination of Aspergillus species from biological samples
- Addressing secondary infections of immunosuppressed individuals or asthmatics
Competitive Advantages
- Easily adapted for use in kits
- Assay may be used in real-time PCR, in enzyme immunoassays and/or in microarrays
- High-throughput capable
Licensing Contact: