Technology ID
TAB-2584
Islet Beta Cell Only M3 Muscarinic Acetylcholine Receptor Knockout Mouse
E-Numbers
E-452-2013-0
Lead Inventor
Wess, Jurgen (NIDDK)
Applications
Therapeutics
Research Materials
Diagnostics
Development Status
In vivo data available (animal)
Lead IC
NIDDK
ICs
NIDDK
Researchers at NIH have developed islet beta cell M3 muscarinic acetylcholine receptor knockout mouse. The mice were generated by crossing floxed mouse M3 muscarinic acetylcholine receptor mice with mice in which Cre recombinase was controlled by the beta-cell specific rat insulin promoter (RIP-Cre mice).
Commercial Applications
Study of the physiological role of beta-cell M3 muscarinic receptors in the regulation of glucose homeostasis and insulin release in vivo.
Competitive Advantages
Allows for study of the role of the M3 receptors in the pancreas without whole body effects confounding the results.
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