Technology ID
TAB-2476

Capillary Viscometer for Measuring Viscosity of Macromolecular Solutions of Biological Relevance

E-Numbers
E-231-2012-0
Lead Inventor
Minton, Allen (NIDDK)
Co-Inventors
Grupi, Asaf (NIDDK)
Applications
Research Materials
Non-Medical Devices
Medical Devices
Development Stages
Pre-Clinical (in vitro)
Development Status
  • Prototype
  • In vitro data available
Lead IC
NIDDK
ICs
NIDDK
A capillary-based device and system for measuring the rheological properties of solutions of synthetic and biological polymers. The device automatically serially dilutes and varies the flow rate of a sample, permitting measurement of solution viscosity across wide ranges of concentration and shear rate without changing samples. The device can rapidly and accurately assay solute stability, solute-solvent and solute-solute interactions in solutions of proteins and other macromolecules of biotechnological and pharmaceutical interest, as well as solution injectability.
Commercial Applications
  • Rapid characterization of composition-dependent rheological properties of candidate biopharmaceuticals and industrial polymers.
Competitive Advantages
  • Automatic variation of solute concentration
  • Automatic variation of shear rate
  • Direct measurement of solution injectability

Request More Info

Licensing Contact:
Knezevic, Vladimir
vlado.knezevic@nih.gov

Patents

  • US
    Provisional (PRV) 61/691,209
    Filed on 2012-08-20
    Status: Abandoned
  • US
    National Stage 14/419,914
    Filed on 2015-02-05
    Status: Abandoned
  • Patent Cooperation Treaty
    (PCT) PCT/US2013/055786
    Filed on 2013-08-20
    Status: Expired

Publications

Collaborations

  • Collaboration

Collaboration Description

  • The National Institute of Diabetes and Digestive and Kidney Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize automated capillary viscometer. For collaboration opportunities, please contact Allen P. Minton at minton@helix.nih.gov or Asaf Grupi at grupia@gmail.com.
Date Published