Technology ID
TAB-1884

Mouse Monoclonal Antibodies to MAD1, a Human Spindle Assembly Checkpoint Protein for Maintaining Chromosomal Segregation

E-Numbers
E-119-2003-0
Lead Inventor
Jeang (Estate), Kuan-teh (NIAID)
Applications
Research Materials
Diagnostics
Therapeutic Areas
Oncology
Lead IC
NIAID
ICs
NIAID
Scientists at the National Institutes of Health have developed mouse monoclonal antibodies against the human spindle assembly checkpoint protein, MAD1. The spindle assembly checkpoint in mitotic cell division regulates the fidelity of chromosome segregation during cell division. MAD1 is an important component of this checkpoint control, which if compromised, can lead to the initiation of cancer cell growth. These monoclonal antibodies are the first available antibodies against MAD1 and can be used in laboratory research and diagnostics.
Commercial Applications
  • Research tool in various laboratory procedures to identify and detect MAD1
  • Diagnostic tool for aneuploidy, the condition of having an abnormal number of chromosomes, which results in birth and dev delopmental defects, such as Down syndrome

Request More Info

Licensing Contact:
Salata, Carol
csalata@mail.nih.gov

Publications

Collaborations

  • Collaboration

Collaboration Description

  • The NIAID NIAID Technology Transfer & Intellectual Property Office is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize reagents for studying cell cycle checkpoint factors.
Date Published