Vitamin C renal leak as a clinical diagnostic tool in the detection, monitoring, and management of acute and chronic diseases
This technology includes a clinical diagnostic tool for measuring vitamin C elimination by human kidneys that can be used for detecting, monitoring, and managing acute and chronic diseases. Findings revealed significant associations between vitamin C renal leak status and clinical variables affecting renal function and blood glucose. The technology uses vitamin C depletion-repletion kinetics and pharmacokinetic models to establish a physiological vitamin C renal threshold. This allowed us to define “vitamin C renal leak” as urinary vitamin C levels below the established minimal elimination threshold. The technology was tested and validated in multiple clinical studies involving more than five cohorts of healthy controls or those with chronic disease.
- Establishment of a commercial service to measure vitamin C renal leak in plasma and urine for diagnostic or management purposes of many conditions (to include but not be limited to diabetes and Fabry disease).
- Vitamin C renal leak may help detect and monitor renal damage in diabetes and other chronic conditions and potentially guide the timeline for protective medications such as ACE/ARBs.
- Vitamin C renal leak may identify patients who would benefit from alternative medications for managing conditions. For example, GLP-1 agonists or SGLT-2 inhibitors may more effectively protect cardiovascular disease patients with vitamin C leaks.
- Vitamin C loss may be a biomarker to indicate the need for earlier treatment of Fabry disease.