Phosphotyrosine mimicking amino acid
Company
Bachem Holding AG
Use
Used as a building block for the synthesis of cell-permeable protein tyrosine phospatase (PTP) inhibitors
Features
Inhibited PTP 1B 20 times more potently than the corresponding phosphotyrosine containing peptide
NIH Contribution
Developed O-Malonyl Tyrosyl – Containing SH2 Domain Inihbitors
HHS Institute/Agency
NCI
Inventor(s)
T. Burke, M. Akamatsu, H. Kole, P. Roller, B. Ye
Year
2004
Tech Cat
Research Reagent
