Growth Arrest and DNA Damage-45
Company
Zymed Laboratories, Inc.
Use
Gadd45 expression has been shown to be dependent on the tumor suppressor and p53 transcription factor
Features
GADD45 is the only known x-ray responsive gene whose induction is not mediated by PKC
NIH Contribution
Identified a critical role Gadd45a that protects the skin against cancer-causing damage from the sun's rays.
HHS Institute/Agency
NCI
Inventor(s)
J. Hildesheim, M Anver, W Alvord, M Hollander, A Fornace
Year
1997
Tech Cat
Research Reagent
