Therapeutic Areas
Infectious Disease
Immunology
LAD2 and LADR cell lines are invaluable tools in mast cell research, offering insights into mastocytosis and immune responses. Derived from CD34+ cells, LAD2 cells have been extensively used for over 18 years, while LADR cells, a newer variant, exhibit enhanced characteristics such as larger size, increased granulation, and faster doubling time. Both cell lines release granular contents upon FceRI aggregation and can be infected with various strains of HIV. LADR cells, in particular, show greater expression of certain surface receptors and mRNA compared to LAD2 cells. Additionally, gene expression arrays highlight differences in signaling pathways and regulatory mechanisms between the two cell lines, providing a comprehensive platform for studying mast cell biology and related diseases.
Commercial Applications
The LAD2 and LADR cell lines have a wide range of potential applications in mast cell research and beyond. Their ability to mimic mast cell behavior and responses makes them valuable tools for studying allergic reactions, inflammatory responses, and immune system modulation. These cell lines can be used to investigate the molecular mechanisms underlying mast cell activation, mediator release, and signaling pathways, leading to a better understanding of mast cell-related diseases such as mastocytosis, allergic disorders, and autoimmune conditions. Furthermore, their susceptibility to HIV infection opens up avenues for studying the interaction between mast cells and the virus, potentially uncovering new therapeutic targets for HIV treatment. The versatility and reliability of LAD2 and LADR cells make them promising candidates for various research applications in immunology, virology, and pharmacology.
Competitive Advantages
The LAD2 and LADR cell lines offer several competitive advantages in mast cell research compared to other models. Firstly, their origin from a patient with aggressive mastocytosis provides a more clinically relevant model for studying mast cell biology and diseases. Secondly, the long-standing use and distribution of LAD2 cells worldwide demonstrate their reliability and reproducibility in experiments. The recent establishment of LADR cells further enhances this model by offering a variant with distinct characteristics, allowing for more diverse and comprehensive studies. Additionally, the ability of both cell lines to be infected with HIV strains provides a unique opportunity to study mast cell interactions with viral infections. Overall, the availability, reliability, and versatility of LAD2 and LADR cells make them highly competitive choices for researchers studying mast cells and related disorders.
