Technology ID
TAB-2442

Rabbit Polyclonal Antibody to Detect a Pro-peptide Fragment of NSAID-activated Gene (NAG-1)/GDF15, a Protein Associated with Cancer

E-Numbers
E-177-2012-0
Lead Inventor
Eling, Thomas (NIEHS)
Applications
Research Materials
Therapeutic Areas
Oncology
Development Status
In vitro data available
Lead IC
NIEHS
ICs
NIEHS
Chronic inflammation is clearly associated with an increase in the risk of cancer. Non-steroidal anti-inflammatory drugs (NSAIDs) are well documented as agents that inhibit tumor growth and with long-term use can prevent tumor development. NSAID-activated gene (NAG-1), a unique member of the TGF-beta superfamily, is highly induced by NSAIDs and numerous drugs and chemicals with anti-tumorigenic activities.

The protein product of NAG-1 is first formed into an immature peptide dimer that must be cut at a specific site before it can be secreted as a mature protein. Currently available antibodies can only detect either the immature form of NAG-1 or the secreted mature protein, but do not recognize the peptide fragment that remains when the immature dimer is cut to form the mature protein. Now available for the first time, the present new antibody recognizes this NAG-1 pro-peptide fragment.
Commercial Applications
    As a research tool to detect expression of the NAG-1/GDF15 cleavage fragment in cells and media from cultured cells.
Competitive Advantages
    No other antibody is currently available to detect the NAG-1/GDF15 pro-peptide fragment.

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Licensing Contact:
Choudhry, Vidita
vidita.choudhry@nih.gov

Related Inventions

Collaborations

  • Collaboration

Collaboration Description

  • The NIEHS is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this antibody. For collaboration opportunities, please contact Sally E. Tilotta, Ph.D. at sally.tilotta@nih.gov.
Date Published