Technology ID
TAB-2577

Intra-bone Drug Delivery Device and Method

E-Numbers
E-165-2012-0
Lead Inventor
Pantin, Jeremy (NHLBI)
Co-Inventors
Hoyt, Robert (NHLBI)
Hunt, Timothy (NHLBI)
Clevenger, Randall (NHLBI)
Aras, Omer (Clinical Center (CC))
Childs, Richard (NHLBI)
Development Status
  • In vitro data available
  • Prototype
Lead IC
NHLBI
ICs
NHLBI
The invention pertains to devices for directly infusing cellular therapeutics into patient bone. The device monitors intra-bone pressure using pressure sensors disposed at its proximal end and adjusts infusion pressures during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods are particularly suitable for use in performing bone marrow transplants, particularly transplants that utilize cord blood as a stem cell source.
Commercial Applications
  • Drug delivery to bones
Competitive Advantages
  • Therapeutic uptake efficiency
  • Drug delivery efficiency
  • Target specificity

Request More Info

Licensing Contact:
Shmilovich, Michael
shmilovm@nih.gov

Related Inventions

Patents

  • US
    National Stage 14/772,044
    Filed on 2015-09-01
  • Patent Cooperation Treaty
    (PCT) PCT/US2014/019401
    Filed on 2014-02-28
  • US
    Provisional (PRV) 61/771,463
    Filed on 2013-03-01

Publications

Collaborations

  • Collaboration

Collaboration Description

  • The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Intra-bone Drug Delivery Device and Method. For collaboration opportunities, please contact Denise Crooks at crooksd@nhlbi.nih.gov.
Date Published