Technology ID
TAB-2697
Species-specific Nucleic Acid Detection Assay for Fungi
E-Numbers
E-232-2013-0
Lead Inventor
Morrison, Christine (CDC)
Co-Inventors
Reiss, Errol (CDC)
Aidorevich, Lilianna (CDC)
Choi, Jong Soo (CDC)
Applications
Therapeutics
Research Materials
Occupational Safety and Health
Diagnostics
Consumer Products
Therapeutic Areas
Ophthalmology
Oncology
Infectious Disease
Endocrinology
Dental
Cardiology
Development Stages
Pre-Clinical (in vitro)
Development Status
In vitro data available
Research Products
Research Equipment
Lead IC
CDC
ICs
CDC
This invention pertains to nucleic acid-based assays for the detection of Aspergillus and other filamentous fungi. Assays cover the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, Absidia, Cunninghamella, Pseudallescheria or Sporthrix in a subject. This can reduce identification time from several days by conventional culture methods to a matter of hours. Furthermore, genus-specific probes are also provided for Aspergillus, Fusarium and Mucor, in addition to an "all-fungus" nucleic acid probe. This technology is readily adaptable as kits used for species-specific identification of opportunistic pathogen infections or possible work/home contamination.
Commercial Applications
- Directing antifungal drug therapy for improved patient outcomes
- Detection, discrimination of fungal species from biological samples
- Addressing secondary infections of immunosuppressed individuals or asthmatics
Competitive Advantages
- Rapid, sensitive, simple and specific
- Cost-efficiency compared to culture or sero-diagnostic methods
- Easily adaptable to kit form
- High-throughput screening
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