Technology ID
TAB-4597
A BL21 (ED3) Codon Plus Competent Cell-derived Bacterial Strain for Research Use
E-Numbers
E-008-2013-0
Lead Inventor
Wade, Paul (NIEHS)
Co-Inventors
Dhasarathy, Archana (University of North Dakota)
Applications
Therapeutics
Research Materials
Development Stages
Pre-Clinical (in vitro)
Research Products
Antibodies
Lead IC
NIEHS
ICs
NIEHS
This technology includes a bacterial strain derived from BL21 (ED3) CodonPlus Competent Cells containing an expression vector for human POLR2C gene for research purposes. The bacterial strain can be used to produce the full-length human RNA polymerase II subunit, RPB3 protein, which can be in turn isolated and purified.
Commercial Applications
Purified RPB3 protein can be used to characterize its biochemical property, and can also be used as an antigen to generate an antibody that can specifically recognize the protein in vivo and or in vitro for research purposes.
Competitive Advantages
Produced human RPB3 protein is particularly valuable to generate an anti-RPB3 antibody that can be used as a research tool. Currently available antibody against the protein was produced using the Drosophila homologue; therefore, it is not optimal for detecting human protein.
Licensing Contact: