Technology ID
TAB-4607

Discovery of Novel SHT (SHT6) Compounds for the Treatment of Central Nervous System-related Diseases

E-Numbers
E-063-2019-0
Lead Inventor
Iyer, Malliga (National Institute on Alcohol Abuse and Alcoholism (NIAAA))
Co-Inventors
Kim, Kyu (National Institute on Alcohol Abuse and Alcoholism (NIAAA))
Applications
Therapeutics
Therapeutic Areas
Psychiatry/Mental Health
Neurology
Metabolic Disease
Endocrinology
Development Stages
Pre-Clinical (in vitro)
Research Products
Human Cell Lines
Computational models/software
Lead IC
NIAAA

This technology includes novel compounds which can be expected to selectively target the 5HT6 receptor, which is implicated in CNS-related diseases. In particular 5HT6 antagonism has been implicated in cognitive impairment, AD/PD and drug abuse/alcohol abuse related disorders. 5HT6 compounds have also shown to reduce appetite and induce weight loss. As such, compounds that can selectively antagonize 5HT6 along with an additional signaling pathway implicated in such diseases like inducible nitric oxide synthase (iNOS) may be valuable for such CNS mediated diseases. Here in we have designed and synthesized compounds which can have unique 5HT6 antagonism as well as iNOS inhibition to offer additive benefits or synergism in alleviating memory and cognitive deficits, reduce obesity and food/drug intake.

Commercial Applications
Potential to be developed to treat CNS-related diseases and obesity.

Competitive Advantages
The designed and synthesized compounds can have SHT6 antagonism as well as iNOS inhibition to offer additive benefits or synergism in alleviating memory and cognitive deficits in AD/PD, reduce obesity and food/drug intake over previously tested monotherapy.

Request More Info

Licensing Contact:
Shmilovich, Michael
shmilovm@nih.gov

Collaborations

  • Licensing
  • Collaboration

Collaboration Description

  • We are seeking statements of capability or interest from parties interested in collaborative research to further developer, evaluate, or commercialize this technology.
Date Published